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KMID : 0359819930220020287
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 2 p.287 ~ p.299
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Electroencephalographic, Behavioral and Pathologic Characteristics in Experimental Complex Partial Seizure Induced by Microinjection of Kainic Acid into the Unilateral Amygdala in the Rat
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Abstract
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Kainic acid (KA) is an excitotoxic analogue of glutamate which is now widely used in the studies of epilesy. Electroencephalographic, behavioral and pathologic observation were done for 2 months after microinjection of kainic acid (Kainic acid
group ;
0.4 μg, 0.8μg, 1.2μg, 1.6μg, 2.0μg, 3.0μg) and phosphate buffer solution (Control group) into the left basolateral amygdala (AMG) in 30 Spaque-Doley rats.
The control group showed no change in EEG and behavior during the observation period of six rats of 1.6μg, all six rats of 2.0μg, one of four rats of 3.0μg developed acute complex partial seizure and multiple epileptic spikes with high
amplitude
in
EEG. One of four rats of 1.2μg, one of six rats of 1.6μg, three of six rats of 2.0μg, showed spontaneous limbic seizure 14~21days after kaininc acid injection. Among those which developed spontaneous limbic seizure, two rats demonstrated
spontaneous
secondarily generalized seizure 30~60days after kainic acid injection.
Pathological examination revealed focal necrosis with perifocal gliosis at the tip of the cannula in the left amygdala. Neuronal cell loss was observed in the CA3 portion of pyramydal cell layer of the hippocampus on the injected side of KA,
which
developed spontaneous secondarily generalized seizure. But the cellular architecture was normal in the contralateral hippocampus. This is regarded as a good model of spontaneous generalized complex partial seizure, which is similar to that of
temporal
lobe epilepsy in human.
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KEYWORD
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